Skin Concerns
Designed for fine lines and early wrinkles, dull or uneven texture, loss of firmness and elasticity, under-eye dark circles and crepiness, post-acne scarring, and slow post-procedure recovery. Also pairs well with microneedling, lasers, and chemical peels to accelerate healing.
Ideal Candidate
Best for adults 25+ looking for natural-looking skin rejuvenation without injections of filler or toxin. Especially well suited to patients who want predictable, lab-grade results without a blood draw, those recovering from a procedure, and clients with sensitive or reactive skin who don’t tolerate stronger downtime. Not recommended during pregnancy, while breastfeeding, or with active skin infection — consultation determines candidacy.
Treatable Areas
Full face, under-eyes, neck, décolleté, back of hands, and scalp. Commonly combined areas: face + neck, or face + under-eyes. Ask your provider about treating acne-scar zones, stretch-mark areas, and post-surgical sites — off-label use is reviewed case by case during consultation.
What PDGF+ Does
Ariessence Pure PDGF+ delivers pharmaceutical-grade platelet-derived growth factor combined with hyaluronic acid. It supports healing, stimulates collagen production, and smooths fine lines.
Because it’s lab-manufactured rather than blood-derived, the concentration is consistent and the dosage is predictable — unlike PRP or PRF, which vary from draw to draw.
It works well as a standalone treatment for texture and tone, or as a recovery accelerant after laser and microneedling procedures. No blood draw, minimal downtime.
The Benefits
Collagen Production
Activates your body’s natural repair processes, promoting tissue regeneration and faster healing — especially after procedures.
Deep Hydration
The hyaluronic acid carrier delivers sustained moisture while growth factors improve firmness, smooth fine lines, and refine texture.
Gradual, Lasting Results
Produces gradual improvement without volume distortion. Low downtime with reduced redness compared to blood-derived alternatives.
Skin Concerns We Treat
PDGF+ addresses a range of skin quality concerns through growth-factor-driven collagen stimulation — without the variability of a blood draw. Here’s what it targets.
Under-Eye Dark Circles
Dark circles and hollowing under the eyes are caused by thinning skin, visible vasculature, and volume loss in the tear trough area. PDGF+ thickens the dermal layer by stimulating collagen production, reducing the translucency that makes vessels and pigment visible. For patients with significant hollowing in addition to skin quality issues, PRF Undereye or PRF EZ Gel can address the volume component while PDGF+ targets the skin itself.
Fine Lines & Wrinkles
Fine lines form as collagen and elastin production slows with age. PDGF+ delivers a standardized dose of growth factors that activate fibroblasts and stimulate new collagen synthesis, gradually smoothing fine lines over multiple treatments. For dynamic wrinkles caused by repeated muscle movement, Botox or Dysport can be combined to address both the muscular and structural components.
Skin Laxity & Thinning
As the dermis loses collagen density, skin becomes thinner and less resilient — contributing to a crepey texture and reduced firmness. PDGF+ supports the structural matrix by promoting new collagen and elastin at the dermal level. For patients with more advanced laxity, combining PDGF+ with Vivace RF Microneedling can provide deeper tissue remodeling while the growth factors accelerate recovery.
Uneven Texture & Tone
Rough texture, enlarged pores, and uneven tone are often the result of accumulated sun damage, environmental exposure, and slowed cell turnover. PDGF+ stimulates cellular renewal and collagen remodeling that smooths the skin surface over time. Pairing PDGF+ as an add-on to SkinPen microneedling or a chemical peel can amplify texture improvement.
Post-Procedure Recovery
PDGF+ is frequently used as an add-on to laser resurfacing, microneedling, and RF treatments to accelerate the healing process. The growth factors reduce inflammation, support tissue repair, and can shorten the visible recovery window. Common pairings include MOXI laser, BBL Photofacial, and Vivace RF Microneedling.
Dullness & Dehydration
Skin that appears flat, tired, or dehydrated often lacks both moisture and the cellular activity needed for healthy turnover. The hyaluronic acid carrier in PDGF+ delivers immediate hydration while the growth factors support deeper tissue renewal over the following weeks. A HydraFacial or Deluxe Facial between sessions can maintain clarity and moisture.
What to Expect
A standalone PDGF+ treatment takes approximately 30–45 minutes. When used as an add-on to microneedling or laser, it’s incorporated into the existing session time.
Consultation & Assessment
Your provider evaluates your skin, discusses your concerns, and determines whether PDGF+ is best used as a standalone injection or combined with another treatment.
Skin Preparation
The treatment area is thoroughly cleansed. If PDGF+ is being injected rather than applied topically, a numbing cream may be applied for comfort — particularly in sensitive areas like the under-eyes.
PDGF+ Application or Injection
The pharmaceutical-grade growth factor is either injected into targeted areas (under-eyes, nasolabial folds, full face) or applied topically during microneedling. No blood draw involved.
Post-Treatment & SPF
A calming serum and mineral sunscreen are applied. You’ll receive aftercare instructions covering sun protection, product usage, and activity restrictions for the first 24–48 hours.
Results Timeline
Some patients notice improved hydration and brightness within the first week. Collagen-driven improvements in firmness, texture, and fine lines develop gradually over 4–8 weeks. Results compound with each session in a treatment series.
Post-Treatment Tips
Use mineral SPF 30+ daily for at least 2 weeks. Avoid retinoids, active acids, and exfoliants for 3–5 days post-treatment. No makeup for 12–24 hours after injection. Avoid saunas, steam rooms, and strenuous exercise for 24–48 hours. Keep skin hydrated with a gentle moisturizer. For full guidance, visit our post-care instructions.
Treatment Options
PDGF+ can be used as a standalone injection or added to microneedling, laser, or RF treatments to accelerate results. Your provider will recommend the right approach during a consultation.
Stand-Alone PDGF+
A targeted injection of pharmaceutical-grade growth factors to support collagen production, improve skin quality, and accelerate healing.
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PDGF+ Add-On
Add PDGF+ to any microneedling, RF microneedling, or laser resurfacing session to accelerate recovery and support deeper tissue repair.
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How Often to Treat
PDGF+ produces cumulative results — each session builds on the collagen and tissue quality established by the previous one. Your provider will recommend a plan based on your starting point and goals.
The recommended starting protocol for most patients. Each session delivers a standardized dose of growth factors that stimulates collagen production. Spacing sessions 4–6 weeks apart allows each round of collagen remodeling to establish before the next treatment builds on it.
After completing an initial series, periodic sessions maintain the collagen density and skin quality improvements achieved. Maintenance frequency depends on your skin’s response, age, and whether PDGF+ is being combined with other treatments in your overall plan.
When used as an add-on to microneedling, laser, or RF treatments, PDGF+ is applied during the procedure itself. No separate appointment needed — the growth factors are incorporated into the existing session to accelerate healing and support deeper results.
Between PDGF+ sessions, treatments like HydraFacial or a Deluxe Facial can maintain hydration and clarity. For deeper regenerative pairing, ask about PRF EZ Gel or Salmon DNA Facial. View all ELLEMES treatments.
PDGF+ vs. PRP & PRF
All three treatments use growth factors to stimulate collagen and tissue repair. The key difference is the source: PDGF+ is lab-manufactured at a consistent concentration, while PRP and PRF are derived from your own blood and vary from patient to patient.
PDGF+ and PRP/PRF are not interchangeable — each has strengths depending on the concern being treated. Some patients benefit from both in different areas of the face. For an alternative regenerative approach using polynucleotide technology, ask about the Salmon DNA Facial (PDRN). Your provider will recommend the right option during a consultation.
Common Questions
What to know before booking an Ariessence PDGF+ treatment.
How is PDGF+ different from PRP or PRF?
Is PDGF+ a filler?
What skin concerns can it address?
How many treatments are needed?
What is the downtime?
Can it be combined with lasers or microneedling?
Is it safe for all skin types?
How should I prepare and care for my skin?
When You’re Ready
Schedule a consultation and we’ll recommend the right approach based on your skin, your concerns, and your timeline.
Book a Consultation →